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Cytotoxicity tests are conducted by following ISO 10993-5 standard. In general, testing articles are extracted in a cell growth media at predetermined conditions. A sub-confluent monolayer of mammalian cells is exposed to the extract medium and incubated for a specific amount of time at 37 ºC. Following incubation, the morphology of cells is examined by using an optic microscope. The viability of cells is determined quantitively and a reduction of viability by more than 30% is considered a cytotoxic effect. Cytotoxicity is an important indicator for toxicity evaluation of medical devices and biomaterials.


Protein Adhesion

Measurement of the adsorption of human lysozymes to a surface to aid in understanding the overall biocompatibility and functionality of a system in the human body

Biocompatibility: Research
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